UniprotKB/SwissProt ID: Q9JIM1 (Q9JIM1)
Gene Name:
Slc29a1
Organism: Mus musculus (Mouse)
Function: Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:11085929, PubMed:35790189). Functions as a Na(+)-independent transporter (By similarity). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:11085929, PubMed:23639800, PubMed:35790189). Also transports purine (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (By similarity). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis-barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Basolateral cell membrane. Apical cell membrane. Cell membrane
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