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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Vesicle-associated membrane protein 7

UniprotKB/SwissProt ID: Q9JHW5 (Q9JHW5)

Gene Name: Vamp7

Organism: Rattus norvegicus (Rat)

Function: Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasmic vesicle, secretory vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Late endosome membrane. Lysosome membrane. Endoplasmic reticulum membrane. Cytoplasmic vesicle, phagosome membrane. Synapse, synaptosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011012 Longin-like_dom_sf
IPR010908 Longin_dom
IPR001388 Synaptobrevin-like
IPR051097 Synaptobrevin-like_transport
IPR042855 V_SNARE_CC

The S-nitrosylation sites of Q9JHW5

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 21 GTTILAKHAW C GGNFLEVTEQ