UniprotKB/SwissProt ID: Q9JHL4 (Q9JHL4)
Gene Name:
Dbnl
Organism: Rattus norvegicus (Rat)
Function: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Cell membrane. Synapse. Perikaryon. Cell projection, neuron projection. Cell projection, dendrite. Postsynaptic density. Golgi apparatus membrane. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell projection, podosome. Early endosome
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