UniprotKB/SwissProt ID: Q9JHE5 (Q9JHE5)
Gene Name:
Slc38a2
Organism: Rattus norvegicus (Rat)
Function: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10747860, PubMed:10811809, PubMed:10859363, PubMed:11716780, PubMed:11756489, PubMed:12054432, PubMed:16629640, PubMed:18319257, PubMed:18330498, PubMed:18832333, PubMed:19589777, PubMed:21158741, PubMed:27355203). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1 (PubMed:10747860, PubMed:10811809, PubMed:10859363, PubMed:11716780, PubMed:11756489, PubMed:12054432, PubMed:16629640, PubMed:18319257, PubMed:19589777, PubMed:21158741). May function in the transport of amino acids at the blood-brain barrier (PubMed:12021389). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (By similarity). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (PubMed:18832333). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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