Protein Name:
Golgi-associated PDZ and coiled-coil motif-containing protein
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UniprotKB/SwissProt ID: Q9HD26 (Q9HD26)
Gene Name:
GOPC
Organism: Homo sapiens (Human)
Function: Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Golgi apparatus membrane. Golgi apparatus, trans-Golgi network membrane. Synapse. Postsynaptic density. Cell projection, dendrite
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9HD26
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
408 |
LEGGGNPGAS C KDTSGEIKVL |
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