Protein Name:
Endoplasmic reticulum transmembrane helix translocase
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UniprotKB/SwissProt ID: Q9HD20 (Q9HD20)
Gene Name:
ATP13A1
Organism: Homo sapiens (Human)
Function: Endoplasmic reticulum translocase required to remove mitochondrial transmembrane proteins mistargeted to the endoplasmic reticulum (PubMed:32973005, PubMed:36264797). Acts as a dislocase that mediates the ATP-dependent extraction of mislocalized mitochondrial transmembrane proteins from the endoplasmic reticulum membrane (PubMed:32973005). Specifically binds mitochondrial tail-anchored transmembrane proteins: has an atypically large substrate-binding pocket that recognizes and binds moderately hydrophobic transmembranes with short hydrophilic lumenal domains (PubMed:32973005)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9HD20
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
336 |
GRSPQENLVP C DVLLLRGRCI |
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| 2 |
410 |
TTGLKPVDSG C VAYVLRTGFN |
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| 3 |
648 |
SYEKLGSTDL C YIAAVKGAPE |
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