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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: rRNA methyltransferase 3, mitochondrial

UniprotKB/SwissProt ID: Q9HC36 (Q9HC36)

Gene Name: MRM3

Organism: Homo sapiens (Human)

Function: S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA (PubMed:24036117, PubMed:25009282, PubMed:25074936, PubMed:35177605). Also required for formation of 2'-O-methyluridine at position 1369 (Um1369) mediated by MRM2 (PubMed:35177605)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029028 Alpha/beta_knot_MTases
IPR053888 MRM3-like_sub_bind
IPR029064 Ribosomal_eL30-like_sf
IPR051259 rRNA_Methyltransferase
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd
IPR029026 tRNA_m1G_MTases_N

The S-nitrosylation sites of Q9HC36

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 235 TILRSAAGAG C SKVLLTKGCV   
2 244 GCSKVLLTKG C VDAWEPKVLR   
3 290 PDTRVYVADN C GLYAQAEMSN   
4 309 SNKASDHGWV C DQRVMKFHKY