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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Echinoderm microtubule-associated protein-like 4
UniprotKB/SwissProt ID: Q9HC35 (Q9HC35)

Gene Name: EML4

Organism: Homo sapiens (Human)

Function: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Midbody

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR055442 Beta-prop_EML-like_2nd
IPR055439 Beta-prop_EML_1st
IPR005108 HELP
IPR011047 Quinoprotein_ADH-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR036322 WD40_repeat_dom_sf
IPR001680 WD40_rpt
IPR050630 WD_repeat_EMAP
The S-nitrosylation sites of Q9HC35
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 311 TQRHYLGHTD C VKCLAIHPDK   
2 314 HYLGHTDCVK C LAIHPDKIRI   
3 610 THPFKDLLLT C AQDRQVCLWN   
4 638 WTRLVDEPGH C ADFHPSGTVV   
5 820 FCKVHLFQYP C SKAKAPSHKY