Protein Name:
Kinetochore protein Spc25
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UniprotKB/SwissProt ID: Q9HBM1 (Q9HBM1)
Gene Name:
SPC25
Organism: Homo sapiens (Human)
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14699129, PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9HBM1
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
27 |
WNKFKSTDTS C QMAGLRDTYK |
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