UniprotKB/SwissProt ID: Q9HAJ7 (Q9HAJ7)
Gene Name:
SAP30L
Organism: Homo sapiens (Human)
Function: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676) Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3 Functions as a transcription repressor; its activity is marginally lower than that of isoform 1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleolus. Nucleus, nucleolus
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