Protein Name:
Histone-lysine N-methyltransferase EHMT1
|
UniprotKB/SwissProt ID: Q9H9B1 (Q9H9B1)
Gene Name:
EHMT1
Organism: Homo sapiens (Human)
Function: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9H9B1
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1045 |
PSNYKYVSQN C VTSPMNIDRN |
|
|
|
| 2 |
1153 |
LQDIPPGTFV C EYVGELISDS |
|
|
|
| 3 |
19 |
VPARGEPQQD C CVKTELLGEE |
|
|
|
| 4 |
20 |
PARGEPQQDC C VKTELLGEET |
|
|
|
| 5 |
540 |
REITTLANNQ C MATESVDHEL |
|
|
|
| 6 |
553 |
TESVDHELGR C TNSVVKYELM |
|
|
|
|
