Protein Name:
Thiol S-methyltransferase TMT1A
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UniprotKB/SwissProt ID: Q9H8H3 (Q9H8H3)
Gene Name:
TMT1A
Organism: Homo sapiens (Human)
Function: Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes (PubMed:37137720). Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface (PubMed:34980213). Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival (PubMed:34226523, PubMed:34790668). Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles (PubMed:19773358) (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Lipid droplet. Endoplasmic reticulum. Membrane. Microsome. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H8H3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
79 |
SGKLSLLEVG C GTGANFKFYP |
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