Protein Name:
E3 ubiquitin-protein transferase RMND5A
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UniprotKB/SwissProt ID: Q9H871 (Q9H871)
Gene Name:
RMND5A
Organism: Homo sapiens (Human)
Function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H871
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
SDISSVGIDG C WQADSQRLLN |
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| 2 |
139 |
QGMLDVAEEL C QESGLSVDPS |
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| 3 |
25 |
LHKFSGYGQL C ERGLEELIDY |
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| 4 |
308 |
NIKAVIEQRQ C TGVWNQKDEL |
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