Protein Name:
Complex I assembly factor ACAD9, mitochondrial
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UniprotKB/SwissProt ID: Q9H845 (Q9H845)
Gene Name:
ACAD9
Organism: Homo sapiens (Human)
Function: As part of the MCIA complex, primarily participates in the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation (PubMed:20816094, PubMed:24158852, PubMed:32320651). This moonlighting protein also has a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation (PubMed:20816094, PubMed:24158852). In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein (PubMed:24158852)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H845
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
179 |
LASGEHIAAF C LTEPASGSDA |
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| 2 |
271 |
DKLGIRGSNT C EVHFENTKIP |
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| 3 |
327 |
RLIEMTAEYA C TRKQFNKRLS |
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| 4 |
507 |
SANKFEENTY C FGRTVETLLL |
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| 5 |
613 |
QQILEKRAYI C AHPLDRTC-- |
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