Protein Name:
3'-5' RNA helicase YTHDC2
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UniprotKB/SwissProt ID: Q9H6S0 (Q9H6S0)
Gene Name:
YTHDC2
Organism: Homo sapiens (Human)
Function: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321, PubMed:29970596). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs (By similarity). Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H6S0
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1211 |
SSADTEFSDE C TTAERVLMKS |
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| 2 |
1265 |
STDSSSYPSP C ASPSPPSSGK |
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| 3 |
25 |
GGGGGGGPSP C GPGGGGRAKG |
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| 4 |
853 |
KMVLCAVVLK C LDPILTIACT |
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