Protein Name:
HEAT repeat-containing protein 1
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UniprotKB/SwissProt ID: Q9H583 (Q9H583)
Gene Name:
HEATR1
Organism: Homo sapiens (Human)
Function: Ribosome biogenesis factor; required for recruitment of Myc to nucleoli (PubMed:38225354). Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (PubMed:17699751). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in neuronal-lineage cell proliferation (PubMed:38225354)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H583
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
113 |
PYFLLKPAQK C LEWLIHRFHI |
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| 2 |
1237 |
VPTLFNLLSR C LEPLPQEQGN |
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| 3 |
182 |
PLAKGTLITH C YKDLGFMDFI |
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| 4 |
631 |
IAIYLSKSGI C SLHPLLRGWE |
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