Protein Name:
E3 ubiquitin-protein ligase NRDP1
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UniprotKB/SwissProt ID: Q9H4P4 (Q9H4P4)
Gene Name:
RNF41
Organism: Homo sapiens (Human)
Function: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H4P4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
106 |
LDNLMSHLSD C EHNPKRPVTC |
CCCCCCCCCC C CCCCCCCCCC |
5.28% |
24105792
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| 2 |
134 |
MPKDELPNHN C IKHLRSVVQQ |
CCCCCCCCCC C CCCCCCCCCC |
3.22% |
24105792
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| 3 |
238 |
VIKRSLVESG C PASIVNELIE |
CCCCCCCCCC C CCCCCCCCCC |
3.37% |
24105792
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