Protein Name:
Tyrosine-protein phosphatase non-receptor type 23
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UniprotKB/SwissProt ID: Q9H3S7 (Q9H3S7)
Gene Name:
PTPN23
Organism: Homo sapiens (Human)
Function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasmic vesicle. Endosome. Cytoplasm, cytoskeleton, cilium basal body. Early endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H3S7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1466 |
VLQRHGVPPP C KPLASASISQ |
CCCCCCCCEE E EEHHHHCCCC |
9.76% |
22178444
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| 2 |
425 |
SHIPPQLMEK C AALSVRPDTV |
CCCCCCCCEE E EEHHHHCCCC |
1.38% |
37478858
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| 3 |
628 |
QNLAAQDRVL C ALTEANVQYA |
CCCCCCCCEE E EEHHHHCCCC |
2.39% |
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| 4 |
65 |
AVRVPRDFEG C SVLRKYLGQL |
CCCCCCCCEE E EEHHHHCCCC |
1.68% |
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