Protein Name:
Pinin
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UniprotKB/SwissProt ID: Q9H307 (Q9H307)
Gene Name:
PNN
Organism: Homo sapiens (Human)
Function: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Component of the PSAP complex which binds RNA in a sequence-independent manner and is proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus speckle. Cell junction, desmosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H307
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
249 |
PHLFYIPGRM C PATQKLIEES |
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| 2 |
439 |
MEFEIEPDKE C KTLSPGKENV |
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