Protein Name:
Vacuolar protein sorting-associated protein 33B
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UniprotKB/SwissProt ID: Q9H267 (Q9H267)
Gene Name:
VPS33B
Organism: Homo sapiens (Human)
Function: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Required for proper trafficking and targeting of the collagen-modifying enzyme lysyl hydroxylase 3 (LH3) to intracellular collagen (PubMed:28017832). Mediates phagolysosomal fusion in macrophages (PubMed:18474358). Proposed to be involved in endosomal maturation implicating VIPAS39. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical recycling pathway and in the maintenance of the apical-basolateral polarity (PubMed:20190753). Seems to be involved in the sorting of specific cargos from the trans-Golgi network to alpha-granule-destined multivesicular bodies (MVBs) promoting MVBs maturation in megakaryocytes (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome membrane. Lysosome membrane. Early endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Recycling endosome
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Graphical Visualization of S-nitrosylation Sites:
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