Protein Name:
Probable E3 ubiquitin-protein ligase IRF2BPL
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UniprotKB/SwissProt ID: Q9H1B7 (Q9H1B7)
Gene Name:
IRF2BPL
Organism: Homo sapiens (Human)
Function: Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins (PubMed:29374064). Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway (PubMed:29374064). Probably plays a role in the development of the central nervous system and in neuronal maintenance (Probable). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR044882
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I2BP1/2_C3HC4-RING_sf |
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IPR022750
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Interferon_reg_fac2-bd1_2_Znf |
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The S-nitrosylation sites of Q9H1B7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
758 |
KAQGATGEVY C PSGEKCPLVG |
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