Protein Name:
Protein mono-ADP-ribosyltransferase PARP12
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UniprotKB/SwissProt ID: Q9H0J9 (Q9H0J9)
Gene Name:
PARP12
Organism: Homo sapiens (Human)
Function: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins (PubMed:25043379, PubMed:34969853). Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication (PubMed:34187568). Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4 (PubMed:39888989). Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1 (PubMed:34969853). Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation (PubMed:39465252)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Golgi apparatus, trans-Golgi network. Cytoplasm, Stress granule
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H0J9
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
474 |
SPQDVTTMQT C NTKFPGPKSI |
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