Protein Name:
5'-3' exoribonuclease 2
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UniprotKB/SwissProt ID: Q9H0D6 (Q9H0D6)
Gene Name:
XRN2
Organism: Homo sapiens (Human)
Function: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H0D6
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
159 |
EEIKERFDSN C ITPGTEFMDN |
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| 2 |
296 |
KHDELADSLP C AEGEFIFLRL |
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| 3 |
557 |
CWVLRYYYQG C ASWKWYYPFH |
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| 4 |
736 |
EEAILPDQIV C SPVPMLRDLT |
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