Protein Name:
Mitochondrial disaggregase
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UniprotKB/SwissProt ID: Q9H078 (Q9H078)
Gene Name:
CLPB
Organism: Homo sapiens (Human)
Function: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins (PubMed:32573439, PubMed:34115842, PubMed:35247700, PubMed:36170828, PubMed:36745679). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (PubMed:31522117). Plays a role in granulocyte differentiation (PubMed:34115842)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion intermembrane space
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9H078
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
267 |
RLNNRASFKG C TALHYAVLAD |
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| 2 |
446 |
GGQLTKKLKQ C PNAVVLFDEV |
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