Protein Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
|
UniprotKB/SwissProt ID: Q9GZU7 (Q9GZU7)
Gene Name:
CTDSP1
Organism: Homo sapiens (Human)
Function: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
