Protein Name:
Eukaryotic translation initiation factor 5A
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UniprotKB/SwissProt ID: Q9GU68 (Q9GU68)
Gene Name:
eEF5
Organism: Drosophila melanogaster (Fruit fly)
Function: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Functions as a regulator of autophagy (PubMed:19546244)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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