UniprotKB/SwissProt ID: Q9GNK5 (Q9GNK5)
Gene Name:
PGRP-LC
Organism: Drosophila melanogaster (Fruit fly)
Function: Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response (PubMed:11872802, PubMed:22022271). Required for Relish processing and nuclear translocation following proteolytic cleavage (PubMed:11872802). Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria (PubMed:11872802). The different isoforms probably display different recognition capabilities to various microbial patterns (PubMed:12777387, PubMed:16006509) Mediates the response to LPS and Gram-negative bacteria Mediates the response to LPS, peptidoglycan and Gram-negative bacteria
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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