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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Leucine aminopeptidase

UniprotKB/SwissProt ID: Q9FY49 (Q9FY49)

Gene Name: LKHA4

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR045357 Aminopeptidase_N-like_N
IPR042097 Aminopeptidase_N-like_N_sf
IPR016024 ARM-type_fold
IPR049980 LTA4H_cat
IPR038502 M1_LTA-4_hydro/amino_C_sf
IPR034015 M1_LTA4H
IPR001930 Peptidase_M1
IPR015211 Peptidase_M1_C
IPR014782 Peptidase_M1_dom
IPR027268 Peptidase_M4/M1_CTD_sf

The S-nitrosylation sites of Q9FY49

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 193 EAGSLGSSLW C GEDRVVEEFA