UniprotKB/SwissProt ID: Q9FK25 (Q9FK25)
Gene Name:
OMT1
Organism: Arabidopsis thaliana (Mouse-ear cress)
Function: Methylates OH residues of flavonoid compounds. Converts quercetin into isorhamnetin. Dihydroquercetin is not a substrate. Catalyzes the methylation of monolignols, the lignin precursors. Does not contribute to the phenylpropanoid pattern of the pollen tryphine, but is probably confined to isorhamnetin glycoside biosynthesis (PubMed:10700397, PubMed:12777055, PubMed:20652169, PubMed:22258746). Involved in melatonin biosynthesis (PubMed:25039887, PubMed:25250906, PubMed:32354877). Functions as an acetylserotonin O-methyltransferase that catalyzes the transfer of a methyl group onto N-acetylserotonin (NAS), producing melatonin (N-acetyl-5-methoxytryptamine) (PubMed:25039887, PubMed:25250906). Can also methylate serotonin into 5-methoxytryptamine (5-MT) with low catalytic activity (PubMed:25250906). Implicated in melatonin-dependent circadian dynamics of stomatal aperture to minimize night water loss and promote drought tolerance (PubMed:32064655). Prevents the accumulation of oil and anthocyanin content in mature seeds, as well as mucilage production in the seed coat, in a melatonin-dependent manner (PubMed:32354877)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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