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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Sorbitol dehydrogenase

UniprotKB/SwissProt ID: Q9FJ95 (Q9FJ95)

Gene Name: SDH

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Polyol dehydrogenase that catalyzes the NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), ribitol and xylitol as substrates, leading to the C2-oxidized products D-fructose, D-ribulose and D-xylulose, respectively. To a lesser extent, can also oxidize arabitol, mannitol, lactitol and maltitol in vitro. Is required for sorbitol metabolism. Cannot use NADP(+) as the electron acceptor

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion membrane. Cell membrane. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR013149 ADH-like_C
IPR013154 ADH-like_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR045306 SDH-like

The S-nitrosylation sites of Q9FJ95

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 54 VRVRMKAVGI C GSDVHYLKTM   
2 81 VKEPMVIGHE C AGIIEEVGEE