Protein Name:
Acylglycerol kinase, mitochondrial
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UniprotKB/SwissProt ID: Q9ESW4 (Q9ESW4)
Gene Name:
Agk
Organism: Mus musculus (Mouse)
Function: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively (PubMed:15252046). Phosphorylates ceramide but not sphingosine (PubMed:15252046). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (PubMed:18004883). Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (By similarity). In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 (By similarity). Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane. Mitochondrion intermembrane space
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9ESW4
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
34 |
WGGHWLYGKH C DNLLRRAACQ |
CCHHHHHHHH H HCCCCCEEEE |
4.17% |
21278135
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| 2 |
407 |
KLLPRKLRFF C DPRKREQMLP |
CCHHHHHHHH H HCCCCCEEEE |
6.91% |
21278135
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| 3 |
72 |
KATVFLNPAA C KGKARTLFEK |
CCHHHHHHHH H HCCCCCEEEE |
6.93% |
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