Protein Name:
Fructosamine-3-kinase
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UniprotKB/SwissProt ID: Q9ER35 (Q9ER35)
Gene Name:
Fn3k
Organism: Mus musculus (Mouse)
Function: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:16819943). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets (PubMed:16819943, PubMed:20009024). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (PubMed:31398338). Also able to phosphorylate psicosamines and ribulosamines (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR016477
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Fructo-/Ketosamine-3-kinase |
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IPR011009
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Kinase-like_dom_sf |
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The S-nitrosylation sites of Q9ER35
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
130 |
KSKTRQNTVG C GAEGAEPQGV |
CHHHHHHHHC H HHHHHHHCCC |
3.97% |
21278135
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