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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: EH domain-containing protein 4

UniprotKB/SwissProt ID: Q9EQP2 (Q9EQP2)

Gene Name: Ehd4

Organism: Mus musculus (Mouse)

Function: ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport (PubMed:15930129). During sprouting angiogenesis, in complex with PACSIN2 and MICALL1, forms recycling endosome-like tubular structure at asymmetric adherens junctions to control CDH5 trafficking (PubMed:33972531)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Early endosome membrane. Recycling endosome membrane. Cell membrane. Cell junction, adherens junction

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR040990 DUF5600
IPR045063 Dynamin_N
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR031692 EHD_N
IPR030381 G_DYNAMIN_dom
IPR027417 P-loop_NTPase

The S-nitrosylation sites of Q9EQP2

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 141 FGNAFLNRFM C SQLPNQVLKS  CCCCCCCCCC C CCCCCCCCHH  1.84% 20925432
21278135