Protein Name:
Phosphatidylinositol-3-phosphatase SAC1
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UniprotKB/SwissProt ID: Q9EP69 (Q9EP69)
Gene Name:
Sacm1l
Organism: Mus musculus (Mouse)
Function: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:32931550). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration (By similarity). PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9EP69
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
445 |
KNAWADNANA C AKQYAGTGAL |
CCCHHHHHHH H CCCCHHHEEE |
4.95% |
21278135
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| 2 |
84 |
VITKKMKVGE C FNHAVWRATD |
CCCHHHHHHH H CCCCHHHEEE |
3.21% |
20925432
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