Protein Name:
Enoyl-[acyl-carrier-protein] reductase, mitochondrial
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UniprotKB/SwissProt ID: Q9DCS3 (Q9DCS3)
Gene Name:
Mecr
Organism: Mus musculus (Mouse)
Function: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (PubMed:30266742). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9DCS3
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
169 |
QSAATLGVNP C TAYRMLVDFE |
CCCCCCCCCH H HHHHHHHHHH |
2.61% |
21278135
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| 2 |
263 |
DLPLPRLALN C VGGKSSTELL |
CCCCCCCCCH H HHHHHHHHHH |
2.9% |
21278135
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| 3 |
345 |
IRQGRLTAPS C SEVPLQGYQQ |
CCCCCCCCCH H HHHHHHHHHH |
3.81% |
21278135
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