UniprotKB/SwissProt ID: Q9DCP2 (Q9DCP2)
Gene Name:
Slc38a3
Organism: Mus musculus (Mouse)
Function: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10716701, PubMed:15899884, PubMed:16249471, PubMed:18689705, PubMed:29561757, PubMed:30017230). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10716701, PubMed:15899884, PubMed:16249471, PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10716701, PubMed:16249471, PubMed:18689705). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (PubMed:26490457)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Basolateral cell membrane
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