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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pyrroline-5-carboxylate reductase 3

UniprotKB/SwissProt ID: Q9DCC4 (Q9DCC4)

Gene Name: Pycr3

Organism: Mus musculus (Mouse)

Function: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H. Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR028939 P5C_Rdtase_cat_N
IPR029036 P5CR_dimer
IPR000304 Pyrroline-COOH_reductase

The S-nitrosylation sites of Q9DCC4

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 49 LASAPTDNNL C HFRALGCQTT  CCCCCCCCCC C CCCCCHHHHH  2.87% 21278135