Protein Name:
Peroxisomal bifunctional enzyme
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UniprotKB/SwissProt ID: Q9DBM2 (Q9DBM2)
Gene Name:
Ehhadh
Organism: Mus musculus (Mouse)
Function: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities. Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (PubMed:17442273, PubMed:24075987). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (By similarity). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (By similarity). With HSD17B4, catalyzes the hydration of trans-2-enoyl-CoA and the dehydrogenation of 3-hydroxyacyl-CoA, but with opposite chiral specificity (Probable). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (PubMed:24075987). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9DBM2
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
17 |
LPHSLAMIRL C NPPVNAISPT |
CCCCCCCCCH H HHHHHCCCCC |
5.29% |
22178444
21278135
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| 2 |
231 |
QYPGRLAPET C VRSVQASVKH |
CCCCCCCCCH H HHHHHCCCCC |
1.97% |
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| 3 |
471 |
IGKIGVVVGN C YGFVGNRMLA |
CCCCCCCCCH H HHHHHCCCCC |
2.64% |
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| 4 |
561 |
TRYSPIADML C EAGRFGQKTG |
CCCCCCCCCH H HHHHHCCCCC |
2.43% |
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