Protein Name:
Proline-, glutamic acid- and leucine-rich protein 1
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UniprotKB/SwissProt ID: Q9DBD5 (Q9DBD5)
Gene Name:
Pelp1
Organism: Mus musculus (Mouse)
Function: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9DBD5
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
523 |
KGDRNANSDV C AAALRGLSRT |
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