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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Dual specificity protein phosphatase 3

UniprotKB/SwissProt ID: Q9D7X3 (Q9D7X3)

Gene Name: Dusp3

Organism: Mus musculus (Mouse)

Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines (PubMed:16845380). Specifically dephosphorylates and inactivates ERK1 and ERK2 (PubMed:16845380)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, flagellum axoneme

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR020405 Atypical_DUSP_subfamA
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR000387 Tyr_Pase_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom

The S-nitrosylation sites of Q9D7X3

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 124 AHKNGRVLVH C REGYSRSPTL  CCCCEEEEHH H HHHHHCCCCC  3.1% 21278135
2 171 GPNDGFLAQL C QLNDRLAKEG  CCCCEEEEHH H HHHHHCCCCC  2.62% 21278135