Protein Name:
Iron-sulfur cluster assembly enzyme ISCU
|
UniprotKB/SwissProt ID: Q9D7P6 (Q9D7P6)
Gene Name:
Iscu
Organism: Mus musculus (Mouse)
Function: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9D7P6
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
139 |
ELCLPPVKLH C SMLAEDAIKA |
CCCCCCHHHH H HHHHHHHHCC |
3.56% |
|
| 2 |
70 |
VGTGLVGAPA C GDVMKLQIQV |
CCCCCCHHHH H HHHHHHHHCC |
4.68% |
21278135
|
|
