Protein Name:
SPRY domain-containing SOCS box protein 1
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UniprotKB/SwissProt ID: Q9D5L7 (Q9D5L7)
Gene Name:
Spsb1
Organism: Mus musculus (Mouse)
Function: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (By similarity). Acts as a bridge which links the NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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