Protein Name:
ATP synthase subunit C lysine N-methyltransferase
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UniprotKB/SwissProt ID: Q9D1Z3 (Q9D1Z3)
Gene Name:
Atpsckmt
Organism: Mus musculus (Mouse)
Function: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane
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Graphical Visualization of S-nitrosylation Sites:
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