Protein Name:
Cysteine and histidine-rich domain-containing protein 1
|
UniprotKB/SwissProt ID: Q9D1P4 (Q9D1P4)
Gene Name:
Chordc1
Organism: Mus musculus (Mouse)
Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:16083881). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:16083881). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (By similarity). Involved in stress response (PubMed:20493909). Prevents tumorigenesis (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9D1P4
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
211 |
DFNTFLAQEG C TRGKHVWTKK |
CCEEECCCCC C CCCCCCCCCC |
2% |
|
| 2 |
59 |
DFSDFLSIVG C TKGRHNSEKP |
CCEEECCCCC C CCCCCCCCCC |
2.17% |
21278135
|
|
