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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Threonine--tRNA ligase 1, cytoplasmic
UniprotKB/SwissProt ID: Q9D0R2 (Q9D0R2)

Gene Name: Tars1

Organism: Mus musculus (Mouse)

Function: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR012675 Beta-grasp_dom_sf
IPR004095 TGS
IPR012676 TGS-like
IPR002320 Thr-tRNA-ligase_IIa
IPR018163 Thr/Ala-tRNA-synth_IIc_edit
IPR047246 ThrRS_anticodon
IPR033728 ThrRS_core
IPR012947 tRNA_SAD
The S-nitrosylation sites of Q9D0R2
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 106 SWKTTPYQIA C GISQGLADNT  CCHHHCCCCC C CCCCCCCCCC  5.48%
2 253 VNTPTTTVYR C GPLIDLCRGP  CCHHHCCCCC C CCCCCCCCCC  3.45%
3 260 VYRCGPLIDL C RGPHVRHTGK  CCHHHCCCCC C CCCCCCCCCC  4.13%
4 655 FMADTDLDPG C TLNKKIRNAQ  CCHHHCCCCC C CCCCCCCCCC  4.81% 22178444