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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Arginine--tRNA ligase, cytoplasmic

UniprotKB/SwissProt ID: Q9D0I9 (Q9D0I9)

Gene Name: Rars1

Organism: Mus musculus (Mouse)

Function: Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis (PubMed:12060739). Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd

The S-nitrosylation sites of Q9D0I9

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 293 DEEFKKRAYQ C VVLLQSKNPD  CCHHHHHHHH H HHHHHHHHHH  1.17%
2 32 LTAEIDRLKN C GCLEASPSLE  CCHHHHHHHH H HHHHHHHHHH  3.78%
3 369 DGRKIVFVPG C SVPLTIVKSD  CCHHHHHHHH H HHHHHHHHHH  2.8% 21278135
4 502 KAAQTSVAYG C IKYADLSHNR  CCHHHHHHHH H HHHHHHHHHH  1.26% 21278135
5 638 LKVNMWRMLL C EAVAAVMAKG  CCHHHHHHHH H HHHHHHHHHH  2.51% 22178444
21278135
6 86 INSRLQEVFG C AIRAAYPDLE  CCHHHHHHHH H HHHHHHHHHH  1.61% 21278135