UniprotKB/SwissProt ID: Q9D0A3 (Q9D0A3)
Gene Name:
Arpin
Organism: Mus musculus (Mouse)
Function: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell projection, lamellipodium
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