UniprotKB/SwissProt ID: Q9CZX7 (Q9CZX7)
Gene Name:
Pip4p2
Organism: Mus musculus (Mouse)
Function: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (PubMed:29378918)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Late endosome membrane. Lysosome membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane
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