Protein Name:
Serine hydroxymethyltransferase, mitochondrial
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UniprotKB/SwissProt ID: Q9CZN7 (Q9CZN7)
Gene Name:
Shmt2
Organism: Mus musculus (Mouse)
Function: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By similarity). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640). Associates with mitochondrial DNA (By similarity). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid. Mitochondrion inner membrane. Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of Q9CZN7
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
343 |
AAVAVALKQA C TPMFREYSLQ |
CCCHHHCCCC C CHHHHHHHHH |
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24926564
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| 2 |
412 |
LVSITANKNT C PGDRSAITPG |
CCCHHHCCCC C CHHHHHHHHH |
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20925432
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| 3 |
91 |
SRAALEALGS C LNNKYSEGYP |
CCCHHHCCCC C CHHHHHHHHH |
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20925432
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