Protein Name:
SERPINE1 mRNA-binding protein 1
|
UniprotKB/SwissProt ID: Q9CY58 (Q9CY58)
Gene Name:
Serbp1
Organism: Mus musculus (Mouse)
Function: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:34815424). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (PubMed:34815424). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). Seems to play a role in PML-nuclear bodies formation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, perinuclear region
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of Q9CY58
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
11 |
MPGHLQEGFG C VVTNRFDQLF |
|
|
20925432
21278135
|
|
